Retinoids Are Back
نویسندگان
چکیده
منابع مشابه
Why Topical Retinoids Are Mainstay of Therapy for Acne
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guideli...
متن کاملRetinoids are important cofactors in T cell activation
Murine thymic T cells depleted of antigen-presenting cells proliferate poorly in response to crosslinking anti-CD3 monoclonal antibodies or concanavalin A when cultured in conventional fetal calf serum-containing serum. However, in a serum-free medium formulated to contain, in addition to basic ingredients, insulin, transferrin, albumin, linoleic acid (ITLB), and retinol, proliferation is vigor...
متن کاملRetinoids and cancer.
The synt hetic retinoids represent a new class of drugs wh ich a re highly effective in t he treatment of a broad spectrum of dermatologic d isease, including cystic acne, psori asis, and cutaneous di sorders of keratinization [1 3]. Moreover, t he use of synthetic retinoids in cancer prevent ion and therapy fo r both cutaneous and in te rna l t umors is potent ially the most signi ficant clini...
متن کاملUnderstanding Topical Retinoids
Retinoids have been a mainstay treatment in dermatology for over fifty years . They are synthetic compounds derived from vitamin A. Studies have shown that these derivatives help clear comedonaland inflammatory lesions while controlling the bacteria implicated in most types of acne. Originally marketed as Retin A, these topical retinoids have gone through numerous transformations over the years...
متن کاملRetinoids and Bone
Vitamin A (retinol) can be produced in the body by hydrolysis of retinyl esters or reduction of retinal. Liver and eggs, which are good animal sources of vitamin A, contain retinyl esters. Plant sources such as carrots and spinach contain pro-vitamin A carotenoids, which can be cleaved to retinal. Retinal, also called retinaldehyde, is interconvertible with retinol (Fig. 1). Retinal also serves...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2015
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.15-0402ufm